FAQ’s about Flexofend™

Osteoarhritis generally reffered to as Arthritis 

Knees, Hips and Wrists 

• 12 Million People in South Africa are suffering with Osteoarthritis (1 out of 5 of all South Africans) 

• 1 out of 3 South Africans are struggling with Joint Related Diseases 

• It is a disease of synovial joints, it is characterized by progressive deterioration and loss of articular cartilage with concomitant structural and functional changes in the entire joint, including the synovium, meniscus (in the knee), periarticular ligaments, and subchondral bone.  

• Increase in pro-inflammatory biomarkers causing chronic inflammation 

• which result in chronic joint pain, stiffness, swelling and bone enlargement or ersosion 

Cause (Ethiology) Unknown.  

Even though the pathogenesis (progress and development) of the disease is very well known we don’t know what is causing the disease. 

• No cure 

• It is a deteriorating disease 

• Growing Problem worldwide 

• Osteoarthritis is a leading causes of chronic disability in people older than 70 years 

• one of the most common causes of chronic pain in people 65 years 

• Chronic pain and stiffness 

• Quality of Life impaired drastically 

• The WHO has declared Osteoarthritis as a priority disease  

• Women is at a significant risk with 60% of patients women 

• Market is flooded with product with questionable quality and none to moderate proof of efficacy  

It is connective tissue, covering and protects the bones in the joint area. It cushions the joint and provide  a smooth, lubricated surface for articulation and movement. 

• In the absence of a cure for Joint Related Diseases such as Osteoarthritis there is a enormous need for safe and effective alternatives. 

• The allopathic medicines control pain en inflammation very well but are not safe to use chronically. 

• A product which is safe and effective for chronic use could support such patients a lot.  

• Protection and Movement are the key to long-term joint health and more and more people are looking for a natural alternative to support them.

Flexofend™ is an award winning supplement for Joint Health. Only 1 capsule a day provide people with 3x Joint Defense: 

1. Protect Joints against further damage 

1. Reduce Stiffness 

1. Reduce Pain 

FlexofendTM Protect your joints whilst enhancing Movement. 

FlexofendTM with is 500 mg NEM® (Eggshell Membrane) which contains a natural matrix of bioactive molecules such as  

• proteins including collagen (Types I, V and X), and  

• naturally occurring glycosaminoglycans including glucosamine, chondroitin, keratan sulfate, and hyaluronic19 

The collagen and other proteins appear to work as a unit together with the glycosaminoglycans to help support a healthy inflammatory response.  

The active ingredient NEM® is a source of these powerfull bioactive molecules working synergistically It  promote healthy joints.1,2,4,5 

• Patients struggling with Osteoarthritis or any other joint diseases such as gout and Rheumatoid Arthritis 

• Sportsmen who regularly overuse their joints 

• All people with “healthy” joints wishing to protect their joints against daily wear and tear and deterioation over time 

• Women who is a major risk group for Osteoarthritis 

• One Capsule daily 

• One active ingredient 

• One of the fastest working joint health supplements in South Africa 

• Patient feel it within 10 days (70%) 

• It Protect Joints but also enhance Movement due to the reduction of Pain and Stiffness in the Joints 

• It is an Award Winning Product 

• It is Natural and Safe to use 

• 14 clinical studies published in reputable medicle journals 

• Only Joint Health Supplement with a published clinical trial done in health subjec 

• 1 Capsule per Day 

• Long Term Joint Supplement to Protect and to Support Movement 

• It must be use chronically every day 

• It is recommned to use for at least 6 month to experience optimal results with regards to pain and stiffness.  

NEM® the active ingredient in Flexofend won the Frost & Sullivan award in North America for the best Joint Health Supplement in its category.  

It was awarded due to the fact that it works fast, safe to use, natural and the availability of so many published clinical studies also provide scientific proof of its efficacy  

• Pharmacy 

• Take A Lot  

• Via the webpage www.flexofend.co.za 

• It works exceptionally well for their patients 

• The symptoamtic relief of the product  

• Strong published clinical trials contribute to the trustworthiness of the product  

• Affordable  

• Medical aids Endorsed 

• Unique in the sense that it concurrently Protects and enhance Movement 

• Significant decrease in concurrent analgesic use9 

INFLAMMATION IS NOW WELL ACCEPTED AS A FEATURE OF OSTEOARTHRITIS but we have known about this for 40 years, we just chose to ignore some of the published literature. In a paper published in 1975 George Ehrlich described a cohort of predominantly menopausal females who presented with a deforming and inflammatory OA, some of whom went on to develop changes characteristic of rheumatoid arthritis (RA)  

The pioneering work that Ehrlich did in this area was well recognized by the WHO because of the work that he did for the organization in New York but his work has gained more recognition in recent years and after his death in 2014.  

Many recent studies have shown the PRESENCE OF SYNOVITIS under Osteoarthritis patients and demonstrated a direct association between JOINT INFLAMMATION AND DISEASE PROGRESSION  

Mobasheriet al, 2016, Annals of Physical and Rehabilitation Medicine 59 (2016) 333–339 

• Cartilage and joint pathology protection visible after only 20 days of  supplementation with FlexofendTM11&8 

• NEM® reducing several biomarkers responsible for the deformation of cartilage and fibrous tissue, demonstrating a substantial chondroprotective effect 

• COMP 

• CTX-II 

• IL-1ß 

• TNF-α 

• CRP8 

• In vivo and human clinical studies demonstrate the action in reducing levels of CTX-II, a recognized biomarker of Type II collagen degradation (the predominant collagen type found in cartilage tissue) 

• Cartilage Oligomeric Matrix Protein (COMP) a non-collagen protein of articular cartilage matrix synthesized by chondrocytes and synovial cells. COMP, a well know cartilage degradation biomarker, significantly decreased during NEM® supplementation8 

• Supplementation with NEM® has been shown to promote joint health in women 8,12 

• Flexofend has demonstrated a significant reduction in stiffness in three open label and three double-blind placebo-controlled trials. 

• In a recently completed healthy person clinical trial, a significant reduction in exercise-induced stiffness was demonstrated in only 4 days 

• In vivo and in vitro studies show that Flexofend may promote a healthy inflammatory response. These studies consistently reveal NEM’s selective action in reducing a broad range of pro-inflammatory substances often associated with joint inflammation, such as TNF-α, and both serum and synovial IL-1β.(6-9)  

• NEM supplementation has also been shown to decrease levels of the inflammatory marker, CRP.(8)  

• NEM has also been shown to influence the gene transcription factor NF-κB, which plays a fundamental role in the functioning of the immune system and occurs very early in the inflammatory cascade.*(11

• A new study in a healthy population shows that NEM® may help provide a rapid reduction of exercise-in-duced joint aches and pains.(1)  

• A 2017 randomized, double-blind, placebo-controlled trial (RCT) in a healthy population revealed NEM’s ability to reduce joint pain associated with exercise in healthy individuals in just 8 days.  

• NEM is the first dietary ingredient that has been shown to reduce exercise-induced pain in truly healthy subjects.  

• It has also demonstrated significant reduction in pain in 7-10 days in Osteoarthritis patients in 6 published clinical trials. 

The active ingredient is manufactured in a NSF-Certified GMP facility with a environmentally friendly patented process. The final product is formulated in a GMP SAHPRA approved facility. 

No interaction with any medication is documented during 14 clinical studies and post marketing surveillance in several countries1 

FLEXOFEND™ contains eggshell membrane a natural food sourced ingredient and it should be safe to use during pegnancy breastfeeding.1

Patients with a known egg allergy should consult their doctor or pharmacist prior to using FLEXOFEND™. 

NEM® do not have the concerning side effects associated with other treatments, such as analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and inflammatory cytokinespecific biologicals9